By Montykins
The episode starts with two underwear-clad ladies dancing for Holmes's pleasure. Well, it really starts with almost an hour of the Super Bowl, but we'll ignore that for now. Even the dancing ladies are mostly irrelevant, because they're a pair of thieves that make a habit of handcuffing men to chairs and then robbing them blind. Holmes was anticipating this, so he lets the police in to arrest them.
In the actual story, there's Howard Ennis, a serial killer who's been brought to a hospital so he can donate a kidney to his sister. But he uses mystic arts of the East to pretend to be anesthetized, and then he kills the surgeon and escapes. Those serial killers can be tricky. That's why the FBI sends in Kathryn Drummond, a profiler who's worked this case before. Holmes gets all touchy and angry, because he thinks profiling is ridiculous nonsense, unlike his "deducting," which is of course entirely scientific.
Holmes and Drummond agree that Ennis is probably going to lay low and change his appearance. But what he actually does is run right out and kill everyone in a store, then have someone take his picture. There's also a ridiculously convoluted clue from the hospital, but it's such an obvious red herring that nobody takes it seriously. The real question is why Holmes is so angry at Drummond. It turns out that when they worked together, he slept with her. And then she wrote a mean article about him called "The Deductionist," in which she predicted his self-annihilation from drugs.
It turns out that Ennis is angry at Drummond for claiming that his parents abused him, which resulted in his father's suicide. And his sister didn't really have a bad kidney. So she was in on it, which Drummond only finds out by getting stabbed in the neck. That's what she gets for not answering her phone.
Holmes tracks Ennis to his secret lair, which is an abandoned building that's simply overflowing with chandeliers. Then he provides a brilliant game of wits involving handcuffs and a pistol, but it just ends with him beating Ennis to a pulp with a heavy stick.
And in the other story, Watson apparently has her own rent-controlled apartment somewhere. And she's in danger of being evicted because she sublet it to a guy who shot a porn movie in there. The stakes are pretty low, since we've never seen the place before.